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MEDICA 2019 - World Forum for Medicine
Düsseldorf, GermanyBooth No.: 3/D35-2
AACC Annual Scientific Meeting and Clinical Lab Expo
Anaheim Convention Center ~ Anaheim, CABooth No.: 2627
Thanks to Block Scientific, I was able to procure the re-certified Bayer DCA 2000+ without hassles and get the lab back in operation. The
device works perfectly and I look forward to doing more business with Block Scientific.
--- Mathew Anderson, New Jersey
For the quantitative determination of thyroid stimulating hormone (TSH) concentration in human serum. The assay is useful in the diagnosis of thyroid or pituitary disorders.
The determination of serum or plasma levels of thyroid stimulating hormone (TSH or thyrotropin) is recognized as an important measurement in the assessment of thyroid function.1 Thyroid stimulating hormone is secreted by the anterior lobe of the pituitary gland, and induces the production and release of thyroxine (T4) and triiodothyronine (T3) from the thyroid gland.2 It is a glycoprotein with a molecular weight of approximately 28,000 daltons, consisting of two
chemically different subunits, alpha and beta.3 Although the concentration of TSH in the blood is extremely low, it is essential in the maintenance of normal thyroid function. The release of TSH is regulated by a TSH-releasing hormone (TRH) produced by the hypothalamus.
The levels of TSH and TRH are inversely related to the level of thyroid hormone. When there is a high level of thyroid hormone in the blood, less TRH is released by the hypothalamus, so less TSH is secreted by the pituitary. The opposite action will occur when there are decreased levels of thyroid hormones in the blood. This process, known as a negative feedback mechanism, is responsible for maintaining the proper blood levels of these hormones.4,5 Conventional TSH assays are generally accepted as an important tool in the diagnosis of primary and secondary hypothyroidism1, but offer limited clinical utility in the assessment of hyperthyroidism (overactive thyroid) due to a lack of sensitivity. The Ultrasensitive-TSH ELISA (U-TSH) offers a sensitivity of 0.05 μIU/mL and hence allows
discrimination between hyperthyroid and normal patient populations. The assay is intended to quantitatively measure TSH in human serum with 2nd generation sensitivity. The U-TSH ELISA can be used as an aid in the assessment of thyroid status, and diagnosis and treatment of thyroid disease.