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DRG IGF-1, 96 Wells
IGF-1, 96 Wells
IGF-1, 96 Wells

DRG IGF-1, 96 Wells
Our Price: $320.60
Manufacturer: DRG International Inc.
Regular Price: $387.01
Shipping Info: Shipping Charges Extra
Shipping Weight: 0.9 kg (2 lbs.)

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IGF-1, 96 Wells

This assay is intended for in vitro diagnostic use only.

Clinical Significance

Insulin-like growth factor I (IGF-1) is a polypeptide of 70 amino acids (7650 daltons), and is one of a number of related insulin-like growth factors present in the circulation .The molecule shows approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. The peptide is growth hormone (GH) dependent to a high degree. but there is growing evidence of GH-independent secretion. IGF-1 has numerous growth-promoting effects, including mitogenic effects and the promotion of cartilage sulphation. It may also be implicated in the rate of bone turnover.

Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins, of which six classes (IGF-BPs 1 - 6) are now recognized. BP3 is thought to be the major binding protein of IGF-1, forming a ternary complex of 140 000 daltons with IGF-1 and an acid-labile subunit.

Clinical Applications

The measurement of serum IGF-1 is of recognized value in children with growth disorders and in the diagnosis and monitoring of acromegaly. IGF-1 concentrations change with age, nutritional status, body composition and growth hormone secretion.

A single basal IGF-1 determination is useful in the assessment of short stature in children and in nutritional support studies of acutely ill patients. For the diagnosis of acromegaly, a single IGF-1 determination is considered more reliable than a random GH determination.

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