Guide: A Basic Overview Of Serum Protein Manual Agarose Electrophoresis
June 25th, 2019
Study: Detection Of Benzodiazepines In Oral Fluid By Homogeneous Enzyme Immunoassay
June 20th, 2019
MEDICA 2019 - World Forum for Medicine
Düsseldorf, GermanyBooth No.: 3/D35-2
AACC Annual Scientific Meeting and Clinical Lab Expo
Anaheim Convention Center ~ Anaheim, CABooth No.: 2627
Thanks to Block Scientific, I was able to procure the re-certified Bayer DCA 2000+ without hassles and get the lab back in operation. The
device works perfectly and I look forward to doing more business with Block Scientific.
--- Mathew Anderson, New Jersey
This assay is intended for in vitro diagnostic use only.
Insulin-like growth factor I (IGF-1) is a polypeptide of 70 amino acids (7650 daltons), and is one of a number of related insulin-like growth factors present in the circulation .The molecule shows approximately 50% sequence homology with proinsulin and has a number of biological activities similar to insulin. The peptide is growth hormone (GH) dependent to a high degree. but there is growing evidence of GH-independent secretion. IGF-1 has numerous growth-promoting effects, including mitogenic effects and the promotion of cartilage sulphation. It may also be implicated in the rate of bone turnover.
Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins, of which six classes (IGF-BPs 1 - 6) are now recognized. BP3 is thought to be the major binding protein of IGF-1, forming a ternary complex of 140 000 daltons with IGF-1 and an acid-labile subunit.
The measurement of serum IGF-1 is of recognized value in children with growth disorders and in the diagnosis and monitoring of acromegaly. IGF-1 concentrations change with age, nutritional status, body composition and growth hormone secretion.
A single basal IGF-1 determination is useful in the assessment of short stature in children and in nutritional support studies of acutely ill patients. For the diagnosis of acromegaly, a single IGF-1 determination is considered more reliable than a random GH determination.