Block Scientific, Inc

2'-5'-oligoadenylate synthetase 1, 0.05 mg

FOR RESEARCH USE ONLY.

Related Product Names:
- OAS1 protein; OAS1; OIAS; IFI-4; 2'-5'-oligoadenylate synthetase 1
- EC 2.7.7.-; (2-5')oligo(A) synthetase 1; 2-5A synthetase 1; p46/p42 OAS; E18/E16; 2',5'-oligoadenylate synthetase 1 isoform E16

Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 90%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for OAS1 protein: OAS1; OIAS; IFI-4; EC 2.7.7.-; (2-5')oligo(A) synthetase 1; 2-5A synthetase 1; p46/p42 OAS; E18/E16; 2',5'-oligoadenylate synthetase 1 isoform E16

Function: May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis.

Catalytic Activity: Binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs.

Subunit: Homotetramer.

Subcellular Location: Mitochondrion. Nucleus. Microsome. Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

Induction: By interferons.

Similarity: Belongs to the 2-5A synthetase family.

Summary: This protein is an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. Alternative splicing of this gene produces two isoforms which share identical N-terminal sequence but diverge at exon 7.

2'-5'-oligoadenylate synthetase 1 reacts with human.

OMIM: 164350; gene. [NCBI / EBI]