Stanniocalcin-2, 0.1 mg

FOR RESEARCH USE ONLY.

Related Product Names:
- STC2 protein; STC2; STC-2; STCRP; Stanniocalcin-2
- STC-2; Stanniocalcin-related protein; STCRP; STC-related protein; Stanniocalcin 2

Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 90%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for STC2 protein: STC2; STC-2; STCRP; STC-2; Stanniocalcin-related protein; STCRP; STC-related protein; Stanniocalcin 2

Function: Has an anti-hypocalcemic action on calcium and phosphate homeostasis.

Subunit: Homodimer; disulfide-linked.

Subcellular Location: Secreted protein (Potential).

Tissue Specificity: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood Leucocytes.

Similarity: Belongs to the stanniocalcin family.

Summary: This protein is a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.

Stanniocalcin-2 reacts with human.

OMIM: 603665; gene. [NCBI / EBI]