P27 kip1 protein, 1mg

FOR RESEARCH USE ONLY.

Related Product Names:
- p27 kip1 protein; p27 kip1; KIP1; CDKN4; P27KIP1; P27 kip1 protein
- Cyclin-dependent kinase inhibitor 1B

Fusion: His-Tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 90%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.05% Tween 20.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

This protein is a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.

P27 kip1 protein reacts with human.

OMIM: NCBI [600778]

Pathways:
KEGG pathway: Cell cycle 04110
Reactome Event:Cell Cycle (Mitotic) 69278