Nicotinate-Nucleotide Pyrophosphorylase, 0.05 mg Recombinant Protein

FOR RESEARCH USE ONLY.

Related Product Names:
- QPRT protein; QPRT; QPRTase; Nicotinate-nucleotide pyrophosphorylase
- EC 2.4.2.19; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase; Quinolinate phosphoribosyltransferase; nicotinate-nucleotide pyrophosphorylase (carboxylating)

Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 95%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for QPRT protein: QPRT; QPRTase; EC 2.4.2.19; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase; QPRTase; Quinolinate phosphoribosyltransferase; nicotinate-nucleotide pyrophosphorylase (carboxylating)

Catalytic Activity: Nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

Pathway: NAD biosynthesis; kynurenine pathway; tryptophan to NaMN; seventh (last) step.

Similarity: Belongs to the nadC/modD family.

Summary: This protein is a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

Nicotinate-nucleotide pyrophosphorylase reacts with human.

OMIM: 606248; gene. [NCBI / EBI]