Nicotinamide N-methyltransferase Recombinant Protein, 0.1 mg
FOR RESEARCH USE ONLY.
Related Product Names:
- NNMT protein; NNMT; Nicotinamide N-methyltransferase
- EC 18.104.22.168; Nicotinamide N-methyltransferase
Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.
Synonym Names for NNMT protein: NNMT; EC 22.214.171.124; Nicotinamide N-methyltransferase
Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
Catalytic Activity: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.
Subcellular Location: Cytoplasm.
Tissue Specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.
Similarity: Belongs to the NNMT/PNMT/TEMT family.
Summary: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This protein is the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.
Nicotinamide N-methyltransferase reacts with human.
OMIM: 600008; gene. [NCBI / EBI]