Block Scientific, Inc

Nicotinamide N-methyltransferase Recombinant Protein, 0.1 mg

FOR RESEARCH USE ONLY.

Related Product Names:
- NNMT protein; NNMT; Nicotinamide N-methyltransferase
- EC 2.1.1.1; Nicotinamide N-methyltransferase

Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 95%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for NNMT protein: NNMT; EC 2.1.1.1; Nicotinamide N-methyltransferase

Function: Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.

Catalytic Activity: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide.

Subunit: Monomer.

Subcellular Location: Cytoplasm.

Tissue Specificity: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.

Similarity: Belongs to the NNMT/PNMT/TEMT family.

Summary: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This protein is the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.

Nicotinamide N-methyltransferase reacts with human.

OMIM: 600008; gene. [NCBI / EBI]