G2/Mitotic-Specific Cyclin-B1, 0.05 mg Recombinant Protein

FOR RESEARCH USE ONLY.

Related Product Names:
- CCNB1 protein; CCNB1; CCNB; G2/mitotic-specific cyclin-B1
- Cyclin B1

Fusion: His-Tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 95%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for CCNB1 protein: CCNB1; CCNB; Cyclin B1

Function: Essential for the control of the cell cycle at the G2/M (mitosis) transition.

Subunit: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10.

Developmental Stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis.

Ptm: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.

Similarity: Belongs to the cyclin family. Cyclin AB subfamily.

Summary: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites.

G2/mitotic-specific cyclin-B1 reacts with human.

OMIM: 123836; gene. [NCBI / EBI]

Pathways:
KEGG pathway: Cell cycle 04110
Reactome Event:Cell Cycle (Mitotic) 69278
Reactome Event:Cell Cycle Checkpoints 69620