Epoxide Hydrolase 1, 0.1 mg

FOR RESEARCH USE ONLY.

Related Product Names:
- EPHX1 protein; EPHX1; EPHX; EPOX; MEH; Epoxide hydrolase 1
- EC 3.3.2.3; Microsomal epoxide hydrolase; Epoxide hydratase; Epoxide hydrolase 1, microsomal (xenobiotic)

Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 90%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for EPHX1 protein: EPHX1; EPHX; EPOX; MEH; EC 3.3.2.3; Microsomal epoxide hydrolase; Epoxide hydratase; Epoxide hydrolase 1, microsomal (xenobiotic)

Function: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.

Catalytic Activity: An epoxide + H2O = a glycol.

Subcellular Location: Microsome; microsomal membrane; single-pass membrane protein.

Tissue Specificity: Found in liver.

Disease: Genetic variation in EPHX1 may be associated with susceptibility to a form of pregnancy-induced hypertension known as preeclampsia [MIM:189800]. Hypertension occurs in 5-7% of all pregnancies where it is a leading cause of maternal, fetal and neonatal morbidity and mortality. Among pregnancy-induced hypertension cases, severe preeclampsia is characterized by the development of hypertension and proteinuria after the 20th week of pregnancy and is the most distinctive, life-threatening form.

Disease: Defects in EPHX1 are a cause of familial hypercholanemia (FHCA) [MIM:607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.

Similarity: Belongs to the peptidase S33 family [view classification].

Summary: Epoxide hydrolase plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons.

Epoxide hydrolase 1 reacts with human.

OMIM: 132810; gene+phenotype. [NCBI / EBI]
607748; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Metabolism of xenobiotics by cytochrome P450 00980