Aromatic-L-Amino-Acid Decarboxylase, 1.0 mg

FOR RESEARCH USE ONLY.

Related Product Names:
- DDC protein; DDC; AADC; Aromatic-L-amino-acid decarboxylase
- EC 4.1.1.28; AADC; DOPA decarboxylase; DDC; Dopa decarboxylase (aromatic L-amino acid decarboxylase)

Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 95%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3, 10mM DTT.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for DDC protein: DDC; AADC; EC 4.1.1.28; AADC; DOPA decarboxylase; DDC; Dopa decarboxylase (aromatic L-amino acid decarboxylase)

Function: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Catalytic Activity: L-tryptophan = tryptamine + CO2.

Cofactor: Pyridoxal phosphate.

Pathway: Catecholamine biosynthesis.

Subunit: Homodimer.

Disease: Defects in DDC are the cause of AADC deficiency [MIM:608643]. AADC deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.

Similarity: Belongs to the group II decarboxylase family.

Aromatic-L-amino-acid decarboxylase reacts with human.

OMIM: 107930; gene. [NCBI / EBI]
608643; phenotype. [NCBI / EBI]

Pathways:
KEGG pathway: Alkaloid biosynthesis I 00950
KEGG pathway: Histidine metabolism 00340
KEGG pathway: Phenylalanine metabolism 00360
KEGG pathway: Tryptophan metabolism 00380
KEGG pathway: Tyrosine metabolism 00350