AP-2 Complex Subunit mu-1, 0.1 mg Recombinant Protein

FOR RESEARCH USE ONLY.

Related Product Names:
- AP2M1 protein; AP2M1; CLAPM1; KIAA0109; AP50; AP-2 complex subunit mu-1
- Adaptin mu-1; AP-2 mu-2 chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; Plasma membrane adaptor AP-2 50 kDa protein; HA2 50 kDa subunit; Clathrin assembly protein complex 2 medium chain; Adaptor-related protein complex 2, mu 1 subunit isoform a

Fusion: T7 tag at N-terminus.
Source/Host: E Coli
Purity/Purification: 95%
Crossreactivity: human
Format: 10 mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% NaN3.
Storage: -70 degree C. Avoid frequent freeze and thaw.
Stability: 6-12 months at -70 degree C.
Shipping: Products may be shipped on ice pack or dry ice.

Synonym Names for AP2M1 protein: AP2M1; CLAPM1; KIAA0109; AP50; Adaptin mu-1; AP-2 mu-2 chain; Clathrin coat assembly protein AP50; Clathrin coat-associated protein AP50; Plasma membrane adaptor AP-2 50 kDa protein; HA2 50 kDa subunit; Clathrin assembly protein complex 2 medium chain; Adaptor-related protein complex 2, mu 1 subunit isoform a

Function: Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP50 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositide-containing lipids.

Subunit: Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins (alpha1A/AP2A1 or alpha1B/AP2A1 or alpha2/AP2A2 and beta1/AP2B1), a medium adaptin (mu2/AP2M1) and a small adaptin (sigma2long/AP2S1 or sigma2short/AP2S1). Interacts with ATP6V1H.

Subcellular Location: Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.

Ptm: Phosphorylated (By similarity).

Similarity: Belongs to the adaptor complexes medium subunit family.

Similarity: Contains 1 MHD (mu homology) domain.

Summary: This protein is a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.

AP-2 complex subunit mu-1 reacts with human.

OMIM: 601024; gene. [NCBI / EBI]