17-OH-Progesterone, 96 Wells

Intended Use
The DRG 17-α-OH Progesterone Enzyme Immunoassay Kit provides materials for the quantitative determination of 17-
α-OH Progesterone in serum.

This assay is intended for in vitro diagnostic use only.


Summary and Explanation

The steroid 17-α-Hydroxyprogesterone (17-α-OHP) is produced by both the adrenal cortex and gonads. Even though 17-α-
OHP has relatively little progestational activity, it is of intense clinical interest because it is the immediate precursor to 11-
desoxycortisol (Cpd-S). Because Cpd-S is produced by 21-hydroxylation of 17-α-OHP, measurement of 17-α-OHP is a
useful indirect indicator of 21-hydroxylase activity. In congenital 21-hydroxylase deficiency, the most common variety of
congenital adrenal hyperplasia (CAH), 17-α-OHP is secreted in abundant excess. It is moderately elevated in the 11-β-
hydroxylase deficiency as well. Measurement of 17-α-OHP is therefore valuable in the initial diagnosis of CAH.